The impact of viremia on organ failure, biomarkers and mortality in a Swedish cohort of critically ill COVID-19 patients

Abstract The spread of virus via the blood stream has been suggested to contribute extra-pulmonary organ failure in Coronavirus disease 2019 (COVID-19). We assessed SARS-CoV-2 RNAemia (RNAemia) and association between inflammation, mortality critically ill COVID-19 patients. included all patients with PCR verified consent admitted ICU. RNA copies above 1000/ml measured by plasma was defined as used surrogate for viremia. In this cohort 92 59 (64%) were invasively ventilated. found 31 (34%). Hypertension corticosteroid treatment more common RNAemia. Extra-pulmonary biomarkers extent similar without RNAemia, but former group had renal replacement therapy higher (26 vs 16%; 35 16%, respectively, p = 0.04). not an independent predictor death at 30 days after adjustment age. SARS-CoV2 is a finding ICU COVID-19. Although viremia associated extra pulmonary it who did survive admission. Trial registration: ClinicalTrials NCT04316884.